Product Description:
Polymer Factory's BowtieD® bis-MPA dendrimers are monodisperse, bifunctional scaffolds with an exact number of boc-protected amine and hydroxyl groups at the periphery. After deprotection, the amine surface groups can be used for EDC/DCC coupling or coupling to NHS esters, while the hydroxyl groups can be used for further functionalization to furnish a bifunctional molecules with two modes of activity. Our bis-MPA polyester scaffolds are biodegrable and have low cytotoxicity, making them ideal candidates for use in biological research applications.
 
Related Publications :
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers - Biomaterials, 2012, 33 (7), 1970-1981
Multivalent, bifunctional dendrimers prepared by click chemistry - Chem. Comm., 2005, 0, 5775-5777
Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery - Molecules, 2018, 23 (8), 2028
Fluoride‐Promoted Esterification with Imidazolide‐Activated Compounds: A Modular and Sustainable Approach to Dendrimers - Angew. Chem. Int. Ed., 2015, 54, 2416-2419
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas - PNAS, 2006, 103 (45), 16649-16654
Biological Evaluation of Polyester Dendrimer:  Poly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture - Mol. Pharm., 2005, 2 (2), 129–138