Product Description:
Polymer Factory's bis-MPA NHBOC-acetylene dendrons are monodisperse, multifunctional scaffolds with 1 protected amine focal point and an exact number of acetylene surface groups. After deprotection, the amine focal point can be used for EDC/DCC coupling or coupling to NHS esters, while the acetylene surface groups can be used for click chemistry conjugation such as CuAAC and thiol-yne coupling, yielding highly functional materials. Our bis-MPA polyester scaffolds are biodegrable and have low cytotoxicity, making them ideal candidates for use in biological research applications.
 
Related Publications
 
Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers - Biomaterials, 2012, 33 (7), 1970-1981                               
Multivalent, bifunctional dendrimers prepared by click chemistry - Chem. Comm., 2005, 0, 5775-5777                         
Structurally Diverse Dendritic Libraries:  A Highly Efficient Functionalization Approach Using Click Chemistry -  Macromolecules, 2005, 38 (9), 3663-3678                                
Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research - Chem. Soc. Rev., 2013, 42, 5858-5879                                     
Synthesis and in Vitro Evaluation of Monodisperse Amino-Functional Polyester Dendrimers with Rapid Degradability and Antibacterial Properties - Biomacromolecules, 2017, 18 (12), 4323-4330                       
Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery - Molecules, 2018, 23 (8), 2028